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Metal‐Free Cross‐Dehydrogenative Coupling of Heterocycles with Aldehydes
Author(s) -
Matcha Kiran,
Antonchick Andrey P.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208851
Subject(s) - hypervalent molecule , scope (computer science) , combinatorial chemistry , computer science , coupling (piping) , substrate (aquarium) , coupling reaction , transformation (genetics) , database , chemistry , process engineering , organic chemistry , iodine , materials science , engineering , programming language , catalysis , biochemistry , oceanography , gene , geology , metallurgy
A range of heterocyclic compounds were synthesized by a novel, metal‐free cross‐dehydrogenative coupling between heterocycles and aldehydes under mild reaction conditions that are not sensitive to moisture. The products are formed smoothly and regioselectively at room temperature by a hypervalent iodine mediated transformation. This method has a broad substrate scope and was used in the highly efficient, one‐step synthesis of natural products.