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syn ‐Selective Rhodium(I)‐Catalyzed Allylations of Ketimines Proceeding through a Directed CH Activation/Allene Addition Sequence
Author(s) -
Tran Duc N.,
Cramer Nicolai
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004179
Subject(s) - allene , rhodium , chemistry , imine , sequence (biology) , catalysis , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry
On a Rh‐oll : Rhodium(I)‐catalyzed CH activations of ketimines and subsequent carborhodation of an allene led to an allyl metal species, which then allylated the imine directing group to give highly functionalized methylene dihydroindenyl amines (see scheme) with excellent regio‐ and diastereoselectivity.