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Total Synthesis of (±)‐Hippolachnin A
Author(s) -
Ruider Stefan A.,
Sandmeier Tobias,
Carreira Erick M.
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201410419
Subject(s) - total synthesis , polyketide , yield (engineering) , core (optical fiber) , chemistry , stereochemistry , nanotechnology , computer science , organic chemistry , materials science , telecommunications , biosynthesis , enzyme , metallurgy
Abstract The first total synthesis of the marine polyketide (±)‐hippolachnin A has been achieved in nine linear steps and an overall yield of 9 %. Rapid access to the oxacyclobutapentalene core structure was secured by strategic application of an ene cyclization.