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Parkinsonism induced by solvent abuse
Author(s) -
Uitti Ryan J.,
Snow Barry J.,
Shinotoh Hitoshi,
Vingerhoets Francois J. G.,
Hayward Margo,
Hashimoto Stanley,
Richmond John,
Markey Sanford P.,
Markey Carol J.,
Calne Donald B.
Publication year - 1994
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410350516
Subject(s) - parkinsonism , raclopride , dopaminergic , levodopa , medicine , psychology , disease , parkinson's disease , psychiatry , dopamine
We report the first description of a patient with parkinsonism induced by solvent abuse. Our patient developed parkinsonism acutely, following heavy abuse of lacquer thinner. Her clinical deficits wee indistinguishable from idiopathic parkinsonism (Parkinson's disease) and she responded to levodopa. Parkinsonism has persisted for more than 3 months. Brain computed tomography was normal. Positron emission tomographic studies showed normal fluorodopa uptake and reduced raclopride binding, indicating an unusual disturbance of striatal dopaminergic function. This patient suggests that organic solvents may cause parkinsonism in susceptible individuals.