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Net production of cerebrospinal fluid is decreased by SCH‐23390
Author(s) -
Boyson Sally J.,
Alexander Alice
Publication year - 1990
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410270608
Subject(s) - sch 23390 , choroid plexus , cerebrospinal fluid , endocrinology , medicine , receptor , 5 ht receptor , dopamine , agonist , chemistry , serotonin , pharmacology , central nervous system
A high density of binding sites for the ligands 3 H‐SCH‐23390 and 3 H‐SKF‐83566 has been found in the choroid plexus. Although these sites have similar pharmacology to D 1 dopamine receptors, the high‐affinity component of 3 H‐SCH‐23390 binding in the choroid plexus has been identified as the 5‐HT 1c subtype of serotonin receptor. We investigated the possible role of these receptors in modulating the production of cerebrospinal fluid (CSF) in rats. (R) SCH‐23390 produced up to a 50% decrease in net CSF production, compared to saline. This compound is partial agonist at 5‐HT 1c serotonin receptors, and an antagonist at D 1 dopamine receptors. The (S) enantiomer of SCH‐23390 (SCH‐23388) was ineffective. Drugs interacting with receptors for neurotransmitters in the choroid plexus may hold promise for the treatment of patients with increased intracranial pressure, including those with mass lesions, head trauma, acute or chronic hydrocephalus, or pseudotumor cerebri.