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Accumulation of prion protein in the vagus nerve in creutzfeldt–jakob disease
Author(s) -
Kresl Philip,
Rahimi Jasmin,
Gelpi Ellen,
Aldecoa Iban,
Ricken Gerda,
Danics Krisztina,
Keller Eva,
Kovacs Gabor G.
Publication year - 2019
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.25451
Subject(s) - vagus nerve , prion protein , disease , creutzfeldt jakob syndrome , virology , neuroscience , medicine , pathology , biology , stimulation
Disease‐associated proteins are thought to propagate along neuronal processes in neurodegenerative diseases. To detect disease‐associated prion protein (PrP Sc ) in the vagus nerve in different forms and molecular subtypes of Creutzfeldt–Jakob disease (CJD), we applied 3 different anti‐PrP antibodies. We screened the vagus nerve in 162 sporadic and 30 genetic CJD cases. Four of 31 VV‐2 type sporadic CJD and 7 of 30 genetic CJD cases showed vagal PrP Sc immunodeposits with distinct morphology. Thus, PrP Sc in CJD affects the vagus nerve analogously to α‐synuclein in Parkinson disease. The morphologically diverse deposition of PrP Sc in genetic and sporadic CJD argues against uniform mechanisms of propagation of PrP Sc . Ann Neurol 2019;85:782–787