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Mendelian randomization: Progressing towards understanding causality
Author(s) -
König Inke R.,
Greco Fabiola M. Del
Publication year - 2018
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.25293
Subject(s) - mendelian randomization , causality (physics) , confounding , context (archaeology) , disease , causation , causal inference , medicine , etiology , psychology , clinical psychology , psychiatry , biology , pathology , genetics , physics , quantum mechanics , genetic variants , gene , genotype , paleontology , political science , law
Identifying and understanding factors that cause neurogenerative disorders such as Parkinson's disease (PD) is relevant for a number of reasons. First, the understanding of the pathobiology and etiology of PD is still limited due to the difficulties of conducting laboratory experiments or randomized clinical trials (RCTs), and knowledge of causal influences would give relevant insight into the underlying processes. Second, knowing parameters that lead to the development of the disease could yield plausible candidates for an early prevention of disease progression or therapy. Thus, the search for risk factors that are both modifiable and causal is a relevant endeavor. This article is protected by copyright. All rights reserved.