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AV‐1451 tau and β‐amyloid positron emission tomography imaging in dementia with Lewy bodies
Author(s) -
Kantarci Kejal,
Lowe Val J.,
Boeve Bradley F.,
Senjem Matthew L.,
Tosakulwong Nikki,
Lesnick Timothy G.,
Spychalla Anthony J.,
Gunter Jeffrey L.,
Fields Julie A.,
GraffRadford Jonathan,
Ferman Tanis J.,
Jones David T.,
Murray Melissa E.,
Knopman David S.,
Jack Clifford R.,
Petersen Ronald C.
Publication year - 2017
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24825
Subject(s) - dementia with lewy bodies , dementia , pittsburgh compound b , positron emission tomography , temporal lobe , medicine , alzheimer's disease , nuclear medicine , magnetic resonance imaging , occipital lobe , neuroimaging , pathology , psychology , disease , radiology , psychiatry , epilepsy
Objective Patients with probable dementia with Lewy bodies (DLB) often have Alzheimer's disease (AD)‐related pathology. Our objective was to determine the pattern of positron emission tomography (PET) tau tracer AV‐1451 uptake in patients with probable DLB, compared to AD, and its relationship to β‐amyloid deposition on PET. Methods Consecutive patients with clinically probable DLB (n = 19) from the Mayo Clinic Alzheimer's Disease Research Center underwent magnetic resonance imaging, AV‐1451, and Pittsburgh compound‐B (PiB) PET examinations. Age‐ and sex‐matched groups of AD dementia (n = 19) patients and clinically normal controls (n = 95) from an epidemiological cohort served as a comparison groups. Atlas‐ and voxel‐based analyses were performed. Results The AD dementia group had significantly higher AV‐1451 uptake than the probable DLB group, and medial temporal uptake completely distinguished AD dementia from probable DLB. Patients with probable DLB had greater AV‐1451 uptake in the posterior temporoparietal and occipital cortex compared to clinically normal controls, and in probable DLB, the uptake in these regions correlated with global cortical PiB uptake (Spearman rho = 0.63; p = 0.006). Interpretation Medial temporal lobe AV‐1451 uptake distinguishes AD dementia from probable DLB, which may be useful for differential diagnosis. Elevated posterior temporoparietal and occipital AV‐1451 uptake in probable DLB and its association with global cortical PiB uptake suggest an atypical pattern of tau deposition in DLB. ANN NEUROL 2017;81:58–67