Premium
Cerebrospinal fluid aquaporin‐4 antibody levels in neuromyelitis optica attacks
Author(s) -
Sato Douglas Kazutoshi,
Callegaro Dagoberto,
Haidar Jorge Frederico M.,
Nakashima Ichiro,
Nishiyama Shuhei,
Takahashi Toshiyuki,
Simm Renata Faria,
ApostolosPereira Samira Luisa,
Misu Tatsuro,
Steinman Lawrence,
Aoki Masashi,
Fujihara Kazuo
Publication year - 2014
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24208
Subject(s) - neuromyelitis optica , aquaporin 4 , cerebrospinal fluid , pleocytosis , antibody , medicine , immunology , pathology , astrocyte , myelitis , central nervous system , spinal cord , psychiatry
To elucidate immunopathogenetic roles of aquaporin‐4 antibodies in the cerebrospinal fluid (CSF) of neuromyelitis optica spectrum disorders (NMOSD), we analyzed aquaporin‐4 antibody titers, cellular and inflammatory markers in the CSF collected from 11 aquaporin‐4 antibody seropositive patients. The CSF aquaporin‐4 antibody levels during attacks (but not in sera) closely correlated with pleocytosis, inflammatory cytokines including interleukin‐6 that can regulate antibody‐producing plasmablasts, and glial fibrillary acidic protein levels in the CSF. The amount of aquaporin‐4 antibodies present in the central nervous system may have therapeutic implications, as it is associated with astrocyte injury and inflammatory responses during NMOSD attacks. Ann Neurol 2014;76:305–309