Open AccessIntra‐arterial infusion of fasudil hydrochloride to treat post‐traumatic cerebral vasospasm
Author(s) -
Murakami Tomoaki,
Kajikawa Ryuichiro,
Nakamura Hajime,
Nishida Takeshi,
Yoshimura Kazuhiro,
Yoshihara Tomoyuki,
Tsuruzono Koichiro,
Wakayama Akatsuki,
Kishima Haruhiko
Publication year - 2019
Publication title -
acute medicine and surgery
Language(s) - English
Resource type - Journals
ISSN - 2052-8817
DOI - 10.1002/ams2.420
Subject(s) - fasudil , medicine , subarachnoid hemorrhage , anesthesia , vasospasm , cerebral vasospasm , middle cerebral artery , cardiology , ischemia , biochemistry , signal transduction , chemistry , rho associated protein kinase
Background The effect of intra‐arterial infusion of fasudil hydrochloride in patients with post‐traumatic cerebral vasospasm remains unclear. Here we report a case of intra‐arterial infusion of fasudil hydrochloride for post‐traumatic cerebral vasospasm. Case presentation A 47‐year‐old man was transferred to our hospital with a fractured skull and traumatic subarachnoid hemorrhage. As rhinorrhea of cerebrospinal fluid had not improved, repair surgery was carried out on day 4. Aphasia appeared on day 13. Magnetic resonance imaging and angiography showed an ischemic region in the left temporal lobe and vasospasm of the left middle cerebral artery. We immediately carried out angiography and diagnosed severe vasospasm of the M1 region of the left middle cerebral artery. After placing a microcatheter into the proximal middle cerebral artery, we injected fasudil hydrochloride intra‐arterially. Vasospasm improved and aphasia resolved. Conclusion In this case, intra‐arterial infusion of fasudil hydrochloride was effective against post‐traumatic cerebral vasospasm.