Open AccessSummary of animal models of myelodysplastic syndrome
Author(s) -
Li Weisha,
Li Mengyuan,
Yang Xingjiu,
Zhang Wenlong,
Cao Lin,
Gao Ran
Publication year - 2021
Publication title -
animal models and experimental medicine
Language(s) - English
Resource type - Journals
ISSN - 2576-2095
DOI - 10.1002/ame2.12144
Subject(s) - myelodysplastic syndromes , leukemia , haematopoiesis , animal model , clone (java method) , acute leukemia , phenotype , medicine , bioinformatics , cancer research , biology , gene , immunology , stem cell , bone marrow , genetics
Myelodysplastic syndrome (MDS) is a malignant tumor of the hematological system characterized by long‐term, progressive refractory hemocytopenia. In addition, the risk of leukemia is high, and once it develops, the course of acute leukemia is short with poor curative effect. Animal models are powerful tools for studying human diseases and are highly effective preclinical platforms. Animal models of MDS can accurately show genetic aberrations and hematopoietic clone phenotypes with similar cellular features (such as impaired differentiation and increased apoptosis), and symptoms can be used to assess existing treatments. Animal models are also helpful for understanding the pathogenesis of MDS and its relationship with acute leukemia, which helps with the identification of candidate genes related to the MDS phenotype. This review summarizes the current status of animal models used to research myelodysplastic syndrome (MDS).