Open AccessMouse models of porcine circovirus 2 infection
Author(s) -
Ouyang Ting,
Liu Xiaohui,
Ouyang Hongsheng,
Ren Linzhu
Publication year - 2018
Publication title -
animal models and experimental medicine
Language(s) - English
Resource type - Journals
ISSN - 2576-2095
DOI - 10.1002/ame2.12009
Subject(s) - porcine circovirus , virology , pathogen , pathogenesis , mechanism (biology) , biology , immunology , computational biology , virus , physics , quantum mechanics
PCV 2 is considered the main pathogen of porcine circovirus diseases and porcine circovirus‐associated diseases ( PCVD / PCVAD ). However, the exact mechanism underlying PCVD / PCVAD is currently unknown. Mouse models of PCV 2 are valuable experimental tools that can shed light on the pathogenesis of infection and will enable the evaluation of antiviral agents and vaccine candidates. In this review, we discuss the current state of knowledge of mouse models used in PCV 2 research that has been performed to date, highlighting their strengths and limitations, as well as prospects for future PCV 2 studies.