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Background  To study the antidiabetic effects and mechanisms of the fenugreek extracts in streptozotocin ( STZ )‐induced type 2 diabetic (T2 DM ) mice fed a high‐fat diet ( HFD ).    Methods  We established C57 BL /6J mice model of T2 DM  using  HFD ‐fed and  STZ ‐induced method. Then, the mice were administered with two types of fenugreek extracts (E1, flavonoid and E2, stilbene glycoside) for 4 weeks and the effects on fasting blood glucose ( FBG ), weight, superoxide dismutase ( SOD ), catalase ( CAT ), malondialdehyde ( MDA ), and pathological indexes were investigated.    Results  Administration of fenugreek extracts decreased the  FBG  level compared with that of the model group. Comparatively, the high‐dose E2 decreased the  FBG  more significantly than the other treatments did. Both extracts showed an obvious antioxidant effect by increasing serum  SOD  and  CAT  activities and decreasing the  MDA  content. Furthermore, the high‐dose E1 showed a significant difference ( P  < .01) compared with the model group in the three investigated indexes.    Conclusion  Our study demonstrated that both the flavonoid and stilbene glycoside extracts of fenugreek improved the hyperglycemia in the T2 DM  mice model. Moreover, the antidiabetic effects of both extracts might be due to their antioxidant activity in vivo.

Effects of the fenugreek extracts on high‐fat diet‐fed and streptozotocin‐induced type 2 diabetic mice