Open AccessEffects of the fenugreek extracts on high‐fat diet‐fed and streptozotocin‐induced type 2 diabetic mice
Author(s) -
Li Xiaoyan,
Lu Shuangshuang,
Wang Honglun,
Li Gang,
He Yanfeng,
Liu Xiaoyu,
Rong Rong,
Li Ji,
Lu Xuancheng
Publication year - 2018
Publication title -
animal models and experimental medicine
Language(s) - English
Resource type - Journals
ISSN - 2576-2095
DOI - 10.1002/ame2.12004
Subject(s) - streptozotocin , malondialdehyde , antioxidant , superoxide dismutase , catalase , flavonoid , glycoside , chemistry , oxidative stress , diabetes mellitus , type 2 diabetes mellitus , medicine , traditional medicine , endocrinology , pharmacology , biochemistry , stereochemistry
Background To study the antidiabetic effects and mechanisms of the fenugreek extracts in streptozotocin ( STZ )‐induced type 2 diabetic (T2 DM ) mice fed a high‐fat diet ( HFD ). Methods We established C57 BL /6J mice model of T2 DM using HFD ‐fed and STZ ‐induced method. Then, the mice were administered with two types of fenugreek extracts (E1, flavonoid and E2, stilbene glycoside) for 4 weeks and the effects on fasting blood glucose ( FBG ), weight, superoxide dismutase ( SOD ), catalase ( CAT ), malondialdehyde ( MDA ), and pathological indexes were investigated. Results Administration of fenugreek extracts decreased the FBG level compared with that of the model group. Comparatively, the high‐dose E2 decreased the FBG more significantly than the other treatments did. Both extracts showed an obvious antioxidant effect by increasing serum SOD and CAT activities and decreasing the MDA content. Furthermore, the high‐dose E1 showed a significant difference ( P < .01) compared with the model group in the three investigated indexes. Conclusion Our study demonstrated that both the flavonoid and stilbene glycoside extracts of fenugreek improved the hyperglycemia in the T2 DM mice model. Moreover, the antidiabetic effects of both extracts might be due to their antioxidant activity in vivo.