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The biogenesis and biology of amyloid β oligomers in the brain
Author(s) -
Ashe Karen Hsiao
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12084
Subject(s) - biogenesis , amyloid (mycology) , neuroscience , amyloid β , perspective (graphical) , biology , computational biology , biochemistry of alzheimer's disease , clinical trial , amyloid precursor protein , bioinformatics , medicine , alzheimer's disease , disease , computer science , biochemistry , botany , artificial intelligence , gene
Abstract The repeated failure of clinical trials targeting the amyloid beta (Aβ) protein has challenged the amyloid cascade hypothesis. In this perspective, I discuss the biogenesis and biology of Aβ, from the arrangement of its atoms to its effects on the human brain. I hope that this analysis will help guide future attempts to home in on this elusive therapeutic target.