Open AccessSerum apelin‐13 levels and total oxidant/antioxidant status of patients with Alzheimer’s disease
Author(s) -
Yildiz Zeynep,
Eren Nezaket,
Orcun Asuman,
Münevver Gokyigit Fatma,
Turgay Fatma,
Gündogdu Celebi Lale
Publication year - 2021
Publication title -
aging medicine
Language(s) - English
Resource type - Journals
ISSN - 2475-0360
DOI - 10.1002/agm2.12173
Subject(s) - apelin , oxidative stress , antioxidant , medicine , antioxidant capacity , pathogenesis , disease , endocrinology , alzheimer's disease , gastroenterology , biology , biochemistry , receptor
Objective We aimed to evaluate apelin‐13 levels, total oxidant/antioxidant status in Alzheimer’s disease (AD) and to investigate the relationship between these parameters. Methods Patients newly diagnosed with AD were enrolled in the study. The control group consisted of age‐ and gender‐matched healthy individuals. Serum levels of apelin‐13, total antioxidant status (TAS), and total oxidant status (TOS) were measured. Oxidative stress index was calculated (TOS/TAS) for each participant. Results We reported that serum apelin‐13 and TAS values were significantly lower in the AD group compared with controls, and they found a fair but insignificant relationship between Apelin‐13 and TAS values. Conclusion According to our results, we suggested that insufficient apelin‐13 and TAS levels may contribute to the pathogenesis of AD.