Open AccessEndothelial progenitor cells in cardiovascular diseases
Author(s) -
Qiu Yumin,
Zhang Chanjuan,
Zhang Gaoxing,
Tao Jun
Publication year - 2018
Publication title -
aging medicine
Language(s) - English
Resource type - Journals
ISSN - 2475-0360
DOI - 10.1002/agm2.12041
Subject(s) - progenitor cell , angiogenesis , endothelial progenitor cell , endothelial stem cell , medicine , haematopoiesis , stem cell , progenitor , disease , cancer research , immunology , microbiology and biotechnology , biology , in vitro , genetics
Cardiovascular diseases (CVDs) are the leading cause of death in both developed and developing countries. Endothelial progenitor cells (EPCs) are derived from hematopoietic stem cells with powerful function of angiogenesis. There are many studies on the relation between coronary heart disease and circulating EPCs. In this review, we discuss biological characteristics of endothelial progenitor cells, some influencing factors of the number and function of EPCs, and the role of EPCs in the treatment of cardiovascular disease. At last, we bring some perspectives on the future of endothelial progenitor cell therapy.