Development of acrocyanosis associated with pain and increased creatinine level in histoplasmosis patient: Medication therapy

Amphotericin B is a potential anti‐fungal antibiotic; it is a polyene and shows action on many species of fungi. It is mainly used in life‐ threatening fungal infections and has evidence of producing nephrotoxicity when used in high doses; hence its use is limited. It also shows many dose‐dependent adverse effects; allergic reactions, nausea and vomiting, and an imbalance in electrolytes are other adverse reactions. We report a case of development of acrocyanosis and increased serum creatinine levels on the use of amphotericin B. We describe the rare complications and evaluate the risk factors. Anisodamine was used to treat the acrocyanosis and pain.