Open AccessRole of lncRNAs in aging and age‐related diseases
Author(s) -
He Jieyu,
Tu Chao,
Liu Youshuo
Publication year - 2018
Publication title -
aging medicine
Language(s) - English
Resource type - Journals
ISSN - 2475-0360
DOI - 10.1002/agm2.12030
Subject(s) - senescence , biology , rna , mechanism (biology) , long non coding rna , non coding rna , bioinformatics , neuroscience , microbiology and biotechnology , genetics , gene , philosophy , epistemology
Aging is progressive physiological degeneration and consequently declined function, which is linked to senescence on both cellular and organ levels. Accumulating studies indicate that long noncoding RNA s (lnc RNA s) play important roles in cellular senescence at all levels—transcriptional, post‐transcriptional, translational, and post‐translational. Understanding the molecular mechanism of lnc RNA s underlying senescence could facilitate interpretation and intervention of aging and age‐related diseases. In this review, we describe categories of known and novel lnc RNA s that have been involved in the progression of senescence. We also identify the lnc RNA s implicated in diseases arising from age‐driven degeneration or dysfunction in some representative organs and systems (brains, liver, muscle, cardiovascular system, bone pancreatic islets, and immune system). Improved comprehension of lnc RNA s in the aging process on all levels, from cell to organismal, may provide new insights into the amelioration of age‐related pathologies and prolonged healthspan.