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Background  Recently, some studies have showed that miR‐200 families act as novel biomarkers for the prediction of cancer outcomes.    Aims  This meta‐analysis was designed to investigate the associations between miR‐200 families and the prognosis of patients with various cancers.    Materials & Methods  Eligible published databases including PubMed, Embase and Chinese National Knowledge Infrastructure ( CNKI ) databases were searched for articles until October 18, 2016. We performed a meta‐analysis by calculating pooled hazard ratios ( HR ) and 95% confidence intervals ( CI ). Data were extracted from studies comparing overall survival ( OS ), progression‐free survival ( PFS ) or recurrence‐free survival ( RFS ).    Results  For  OS , the pooled  HR  was 1.54 (95%  CI : 1.01‐2.33), showing that high miR‐200 family was clearly related to poor survival in various carcinomas, but no significantly association was found in  PFS  or  RFS . Subgroup analysis indicated that upregulated miR‐200 family was linked to poor  OS  in Asians ( HR  = 2.19, 95%  CI : 1.27‐3.78) but not in Caucasians ( HR  = 0.94, 95%  CI : 0.46‐1.91). Similarly, high miR‐200 expression could not clearly predict the relationship with  PFS  and  RFS . For cancer type, high miR‐200 also predicted poor  OS  among lung cancer patients ( HR  = 3.09, 95%  CI : 1.75‐5.46). Besides, only elevated miR‐200c of the miR‐200 family indicated a significantly poor  OS  ( HR  = 2.25, 95%  CI : 1.39‐3.64).    Discussion  Aberrant expression of mi RNA s played a crucial role in the area of human carcinomas. Many studies have indicated that mi RNA s are considered promising tumor biomarkers for prognosis and potential targets for clinical treatment. We have testified that high levels of miR‐200 family expression (predominantly miR‐200c) are significantly associated with poor survival and prognostic outcomes of patients with cancers, especially in lung cancer. However, no statistically significant results were calculated for miR‐200a/b and miR‐429, and this might result from a relatively small number of articles about them. In other tumor models except lung cancer, our results indicated that high miR‐200 family was not obviously associated with  OS  (Gastric or Colorectal cancer; Ovarian cancer; Others). In addition, some other records showed the opposite results, for they exhibited that upregulated miR‐200 family level was linked to longer survival. For ethnic group, our stratified analyses showed that the Asian population predicted poor  OS . While the Caucasian population did not exhibit an significant association with  OS . This discrepancy might result from different hereditary backgrounds and environment exposure. Although these results have indicated that miR‐200 families were promising biomarkers to predict prognosis for patients with cancers, there were several limitations in this analysis that would impact its quality. Generally, further studies should be warranted to clarify this question and to provide a new novel idea for routine clinical application.    Conclusion  Our findings suggest that miR‐200 family might be a potentially useful biomarker for predicting cancer prognosis, especially for lung cancer in Asians.

Micro RNA ‐200 families and prognostic value in various carcinomas: A systematic review and meta‐analysis