Hydroxyl Assisted, Photoredox/Cobalt Co‐catalyzed Semi‐Hydrogenation and Tandem Cyclization of  o ‐Alkynylphenols for Access to 2,3‐Dihydrobenzofurans | Zendy

Tian WanFa | Zendy; Zhu Yao | Zendy; He YongQin | Zendy; Wang Mei | Zendy; Song XianRong | Zendy; Bai Jiang | Zendy; Xiao Qiang | Zendy

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Hydroxyl Assisted, Photoredox/Cobalt Co‐catalyzed Semi‐Hydrogenation and Tandem Cyclization of o ‐Alkynylphenols for Access to 2,3‐Dihydrobenzofurans

Author(s) -

Tian WanFa,

Zhu Yao,

He YongQin,

Wang Mei,

Song XianRong,

Bai Jiang,

Xiao Qiang

Publication year - 2021

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202000986

Subject(s) - chemistry , alkene , tandem , cobalt , intramolecular force , catalysis , steric effects , photoredox catalysis , photochemistry , combinatorial chemistry , medicinal chemistry , photocatalysis , organic chemistry , materials science , composite material

Herein, a hydroxyl assisted, photoredox/cobalt co‐catalyzed semi‐hydrogenation and tandem cyclization of o ‐alkynylphenols is developed towards direct assembly of 2,3‐dihydrobenzofurans. Moderate to good yields were obtained for a range of sterically and electronically diverse 2‐propynolphenols under mild conditions. Mechanistic studies demonstrated the inevitable role of the alcoholic hydroxyl group with (Z)‐alkene as the real intermediate. Finally, a key low‐valent cobalt catalyzed intramolecular hydroetherification of alkene is proposed.

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