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A Convenient Synthetic Protocol to 1,2‐Bis(dialkylphosphino)ethanes
Author(s) -
Doyle Laurence R.,
Heath Alex,
Low Choon Heng,
Ashley Andrew E.
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300787
Subject(s) - chemistry , phosphine , reagent , sodium hydride , hydride , combinatorial chemistry , sodium , aqueous solution , organic chemistry , catalysis , metal
1,2‐Bis(dialkylphosphino)ethanes are readily prepared from the parent phosphine oxides, via a novel sodium aluminium hydride/sodium hydride reduction protocol of intermediate chlorophosphonium chlorides. This approach is amenable to multi‐gram syntheses, utilises readily available and inexpensive reagents, and benefits from a facile non‐aqueous work‐up in the final reductive step.