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Palladium‐Catalyzed Reduction of Carboxylic Acids to Aldehydes with Hydrosilanes in the Presence of Pivalic Anhydride
Author(s) -
Fujihara Tetsuaki,
Cong Cong,
Terao Jun,
Tsuji Yasushi
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300451
Subject(s) - chemistry , palladium , pivalic acid , reagent , catalysis , organic chemistry , carboxylic acid , carbonylation , reducing agent , benzoic acid , carbon monoxide
Abstract A palladium catalyst system that allows the reduction of carboxylic acids to the corresponding aldehydes with hydrosilanes as reducing agent and pivalic anhydride as an indispensable reagent has been developed. A simple mixture of commercially available bis(dibenzylideneacetone)palladium(0) [Pd(dba) 2 ], tri( para ‐tolyl)phosphane and methylphenylsilane realized the reduction of various aliphatic carboxylic acids as well as benzoic acids to aldehydes in good to high yields.