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A Microwave‐Enhanced, Lewis Acid‐Catalyzed Synthesis of 1,3‐Dioxolanes and Oxazolines from Epoxides
Author(s) -
Benfatti Fides,
Cardillo Giuliana,
Gentilucci Luca,
Tolomelli Alessandra,
Monari Magda,
Piccinelli Fabio
Publication year - 2007
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600516
Subject(s) - chemistry , lewis acids and bases , catalysis , stereoselectivity , microwave irradiation , lewis acid catalysis , solvent , organic chemistry , microwave , stoichiometry , combinatorial chemistry , physics , quantum mechanics
Abstract A fast and highly regio‐ and stereoselective transformation of non‐conventional β‐lactam‐containing epoxides into the corresponding cyclic 1,3‐dioxolanes and oxazolines is herein reported, using microwave irradiation as an efficient source of energy, in the presence of stoichiometric or catalytic amounts of Lewis acids, without an additional solvent. These cyclic compounds are the protected forms of diols and amino alcohols.