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25th Anniversary Article: Interfacing Nanoparticles and Biology: New Strategies for Biomedicine
Author(s) -
Tonga Gulen Yesilbag,
Saha Krishnendu,
Rotello Vincent M.
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201303001
Subject(s) - interfacing , nanotechnology , biomedicine , materials science , nanomaterials , nanoparticle , computer science , biology , bioinformatics , computer hardware
The exterior surface of nanoparticles (NPs) dictates the behavior of these systems with the outside world. Understanding the interactions of the NP surface functionality with biosystems enables the design and fabrication of effective platforms for therapeutics, diagnostics, and imaging agents. In this review, we highlight the role of chemistry in the engineering of nanomaterials, focusing on the fundamental role played by surface chemistry in controlling the interaction of NPs with proteins and cells.