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Hydrogel Micropillars with Integrin Selective Peptidomimetic Functionalized Nanopatterned Tops: A New Tool for the Measurement of Cell Traction Forces Transmitted through α v β 3 ‐ or α 5 β 1 ‐Integrins
Author(s) -
Rahmouni Sabri,
Lindner Aaron,
Rechenmacher Florian,
Neubauer Stefanie,
Sobahi Tariq Rashad Ali,
Kessler Horst,
CavalcantiAdam Elisabetta Ada,
Spatz Joachim Pius
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201301338
Subject(s) - integrin , materials science , adhesion , cell adhesion , nanotechnology , traction (geology) , ethylene glycol , peptidomimetic , biophysics , cell , composite material , chemistry , biochemistry , biology , peptide , paleontology , organic chemistry
Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α 5 β 1 ‐ and α v β 3 ‐ integrins. Cells adherent via α 5 β 1 ‐integrins have a tendency to exert higher maximum forces than cells adhering via α v β 3 ‐integrins.