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Objective  Acceptance and commitment therapy (ACT) has demonstrated effectiveness in addressing symptoms of anxiety and depression, frequently experienced by patients with systemic lupus erythematosus (SLE). The goal of this pilot study was to develop and assess the feasibility and acceptability of a novel web‐based ACT skills training program tailored for patients with lupus: ACT for Lupus. The program served as a complementary approach to support the management of symptoms and stressors during the COVID‐19 pandemic.    Methods  This study employed a single‐group pretest‐posttest design. Participants with a diagnosis of SLE were primarily recruited through an institutional healthcare system between November 25, 2020 and December 17, 2020 and through an online national lupus organization listserv. Participants were invited to attend two 1‐hour webinars delivered over a 2‐week period. Educational ACT‐based content was tailored for patients with lupus and delivered by an experienced clinical psychologist specializing in ACT. Surveys assessed patient‐reported outcomes of anxiety, depression, and quality of life and evaluated program feedback, usability, and satisfaction.    Results  A total of 83 participants submitted the baseline survey, with 21 participants designated as study completers. The program was well received by participants, who reported feasibility and acceptability of the intervention, as reflected by high usability ratings. Participants reported favorable experiences with the program. Feedback included suggestions to include additional lupus‐tailored content, increase the range and scope of sessions and activities, and improve program flexibility and availability to avoid scheduling conflicts.    Conclusion  This study provides preliminary evidence for an adapted, ACT‐based virtual skills training program as a feasible and acceptable intervention to support the well‐being of patients with lupus.

ACT for Lupus: Pilot Feasibility and Acceptability Study of a Novel Web‐Based Acceptance and Commitment Therapy Program for Patients With Lupus