English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Objective  Many Native American ( NA ) patients with systemic lupus erythematosus ( SLE ) do not exhibit the classical  SLE  autoantibody profiles of European American ( EA ) and African American ( AA ) patients with  SLE . The poorer  SLE  disease outcomes noted in  NA  patients highlights a need for more equitable diagnostic and prognostic tools for  NA  patients with  SLE . The objective was to identify informative autoantibody profiles for  NA ,  AA , and  EA  patients with  SLE  using an expanded set of autoantigens.    Methods  Sera from 49  NA , 49  AA , and 49  EA  age‐, sex‐, and antinuclear autoantibody titer–matched patients with  SLE  who met the American College of Rheumatology classification criteria and 10 ethnicity‐, sex‐, and age‐matched controls were tested for autoantibody reactivity by autoantigen microarrays. Autoantibodies that were significantly elevated in patients with  SLE  compared with ethnicity‐specific controls were selected for hierarchical clustering. Differences in clinical criteria between patient clusters were determined by Fisher's exact test and corrected for multiple comparisons.    Results   NA ,  AA , and  EA  patients with  SLE  each had a cluster distinguished by higher levels of anti‐Ro52 and another cluster distinguished by nucleic acid–specific autoantibodies. Additional clusters were distinguished in  NA  patients by elevated extracellular matrix autoantibodies and were distinguished in  AA  patients by elevated Sm/ RNP  autoantibody and elevated nucleolin/histone autoantibody. Two  EA  patient clusters with similar nucleic acid– and Ro52‐specific autoantibodies were distinguished by either high or low histone 2A reactivity. Renal manifestations trended higher in the  NA  Ro52 cluster and were significantly enriched in the  AA  nucleolin/histone cluster. The  AA  nucleolin/histone cluster and  EA  H2A cluster had higher disease activity.    Conclusion  Expanded autoantibody profiles can identify informative subsets of patients with  SLE .

Expanded Autoantibody Profiles for Subsetting of Native American, African American, and European American Patients With Systemic Lupus Erythematosus