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Objective  Provide state‐level estimates of the number of physically inactive adults in the United States with arthritis and other rheumatic and musculoskeletal diseases ( RMD s) who could improve their anxiety and depression by exercising.    Methods  Utilizing 1) number‐needed‐to treat ( NNT ) data from two prior meta‐analyses of randomized controlled trials addressing the effects of exercise on anxiety and depression in adults with arthritis and other  RMD s, 2) recent state‐level prevalence estimates on arthritis and physical inactivity in adults with arthritis and other  RMD s, and 3) state‐level 2010  US  Census population data, the number of physically inactive adults with arthritis and other  RMD s who could improve their anxiety and depression by exercising was estimated.    Results  Across all states and the District of Columbia, the number of adults with arthritis and other  RMD s who could improve their anxiety and depression by starting an exercise program was estimated at 3 433 167 (95% confidence interval [ CI ] = 3 171 000‐3 703 522) for anxiety and 2 942 706 (95%  CI  = 2 718 000‐3 174 438) for depression. For anxiety, numbers ranged from 3677 (95%  CI  = 3235‐4154) in the District of Columbia to 271 253 (95%  CI  = 243 998‐298 508) in Texas. For depression, numbers ranged from 3151 (95%  CI  = 2773‐3561) in the District of Columbia to 232 502 (95%  CI  = 209 140‐255 863) in Texas.    Conclusion  These state‐specific data suggest that a large number of physically inactive  US  adults with arthritis and other  RMD s could improve their anxiety and depression by starting and maintaining a regular exercise program.

Brief Report: State‐Level Number of Physically Inactive US Adults With Arthritis Who can Improve Their Anxiety and Depression by Exercising