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Systolic Dysfunction in Systemic Sclerosis: Prevalence and Prognostic Implications
Author(s) -
Tennøe Anders H.,
Murbræch Klaus,
Andreassen Johanna C.,
Fretheim Håvard,
Midtvedt Øyvind,
Garen Torhild,
Dalen Håvard,
Gude Einar,
Andreassen Arne,
Aakhus Svend,
Molberg Øyvind,
HoffmannVold AnnaMaria
Publication year - 2019
Publication title -
acr open rheumatology
Language(s) - English
Resource type - Journals
ISSN - 2578-5745
DOI - 10.1002/acr2.1037
Subject(s) - medicine , cardiology , interquartile range , hazard ratio , ejection fraction , prospective cohort study , cohort , systole , proportional hazards model , heart failure , confidence interval , blood pressure , diastole
Objective Primary cardiac involvement is presumed to account for a substantial part of disease‐related mortality in systemic sclerosis ( SS c). Still, there are knowledge gaps on the evolution and total burden of systolic dysfunction in SS c. Here we evaluated prospective left ventricular ( LV ) and right ventricular ( RV ) systolic function in an unselected SS c cohort and assessed the burden of systolic dysfunction on mortality. Methods From the Oslo University Hospital cohort, 277 SS c patients were included from 2003‐2016 and compared with healthy controls. Serial echocardiographies were reevaluated in order to detect change in systolic function. Right heart catheterization was performed on patients suspected of pulmonary hypertension. Descriptive and regression analyses were conducted. Results At baseline, LV systolic dysfunction by ejection fraction less than 50%, or a global longitudinal strain greater than −17.0%, was found in 12% and 24%, respectively. RV systolic dysfunction measured by tricuspid annular plane systolic excursion ( TAPSE ) less than 17 mm was evident in 10%. Follow‐up echocardiography was performed after a median of 3.3 years (interquartile range [ IQR ] 1.5‐5.6). At follow‐up, LV systolic function remained stable, whereas RV function evaluated by TAPSE deteriorated (mean 23.1 to 21.7 mm, P = 0.005) equaling a 15% prevalence of RV systolic dysfunction. RV systolic function predicted mortality in multivariable models (hazard ratio 0.41, 95% confidence interval [ CI ] 0.19‐0.90, P value 0.027), whereas LV systolic function lost predictive significance when adjusted for TAPSE . Conclusion In this unselected and prospective study, systolic dysfunction of the LV and RV was a frequent complication of SS c. LV systolic function remained stable across the observation period, whereas RV function deteriorated and predicted mortality.

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