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Objective  Examine whether pre‐intervention physical activity ( PA ) level is associated with achieving a positive treatment response of pain and/or function improvement after a 12‐week exercise intervention in participants with knee osteoarthritis ( OA ).    Methods  We performed a secondary analysis of a randomized, single‐blind comparative effectiveness trial showing similar treatment effects between Tai Chi mind‐body exercise and standard physical therapy intervention for knee  OA . Baseline  PA  was assessed by a Community Healthy Activities Model Program for Seniors ( CHAMPS ) questionnaire and, in a subsample, by tri‐axial accelerometers. The Outcome Measures in Rheumatoid Arthritis Clinical Trials–Osteoarthritis Research Society International ( OMERACT ‐ OARSI ) dichotomous responder criteria was used for clinically meaningful improvement at follow‐up. Associations between baseline self‐reported  PA  by the  CHAMPS  questionnaire and outcomes of responders vs. nonresponders (reference group) were assessed using logistic regressions, adjusting for demographic covariates. We compared objectively measured  PA  by accelerometry between responders vs. nonresponders using Wilcoxon tests.    Results  Our sample consisted of 166 participants with knee  OA  who completed both baseline and 12‐week postintervention evaluations: mean age 60.7 year ( SD  10.5), body mass index 32.4 kg/m 2  (6.9), 119 (72%) women, and 138 (83%)  OMERACT ‐ OARSI  responders. Neither time spent in total  PA  [odds ratio ( OR ) 1.00; 95% confidence interval ( CI ) 0.96, 1.03] nor time in moderate‐to‐vigorous  PA  ( OR  1.01; 95%  CI  0.93, 1.09) at pre‐intervention were associated with being a responder. Similar findings were observed in 42 accelerometry sub‐cohort participants.    Conclusion  Pre‐intervention  PA  levels (subjective report or objective measurement) were not associated with individuals achieving favorable treatment outcomes after a 12‐week exercise intervention, which suggests that regardless of pre‐intervention  PA  level, individuals will likely benefit from structured exercise interventions.

acr open rheumatology

Association between Pre‐intervention Physical Activity Level and Treatment Response to Exercise Therapy in Persons with Knee Osteoarthritis—An Exploratory Study