English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Objective  Disease Activity Score 28 ( DAS 28)–using the C‐reactive protein (CRP) level has been validated to determine disease activity in rheumatoid arthritis ( RA ) patients during pregnancy. A self‐administered questionnaire like Rheumatoid Arthritis Disease Activity Index ( RADAI ) has practical advantages over  DAS 28‐ CRP , and in this study, we aimed to validate the  RADAI  for use during pregnancy.    Methods  Patients were derived from a prospective cohort on  RA  and pregnancy (Pregnancy‐induced Amelioration of Rheumatoid Arthritis study). To validate the  RADAI  as a disease activity measure, the disease course over time and the disease activity states were compared with the  DAS 28‐ CRP . Furthermore, the  RADAI  was compared with  DAS 28‐ CRP  in predicting fertility and pregnancy outcomes. Finally, to test construct validity, correlation of both  RADAI  and  DAS 28‐ CRP  with a biomarker (galactosylation of immunoglobulin G [IgG]) were determined and compared.    Results  In total, 269 patients were analyzed in this study. Mean  RADAI  scores showed a great decline in disease activity in the first trimester compared with  DAS 28‐ CRP  (mean  RADAI , −1.13; mean,  DAS 28‐ CRP , −0.04). Correlations between  DAS 28‐ CRP  and  RADAI  scores were moderate to good (0.44 <  ρ  < 0.71). Agreement in disease states was low (0.26 <  κ  < 0.51). Time to pregnancy was different between disease states according to  DAS 28‐ CRP  ( P  = 0.03), but not according to  RADAI  ( P  = 0.56). Only  DAS 28‐ CRP  could predict birthweight ( DAS 28‐ CRP  β‐0.17,  P  = 0.04;  RADAI  β‐0.09,  P  = 0.10). Both  DAS 28‐ CRP  and  RADAI  were associated with galactosylation of IgG at specific time points, but only change in  DAS 28‐ CRP  was correlated with change in galactosylation of IgG from preconception to pregnancy.    Conclusion  The  RADAI  could not be validated as a disease activity measure during pregnancy.  DAS 28‐ CRP  remains the gold standard of measuring disease activity in pregnancy.

acr open rheumatology

The Self‐Administered Rheumatoid Arthritis Disease Activity Index ( RADAI ) is Less Accurate than  DAS 28‐ CRP  as a Disease Activity Measure in Pregnancy