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Objective  The present study was undertaken to evaluate the probability of achieving the Clinical Disease Activity Index for Psoriatic Arthritis ( cDAPSA ) treatment targets of remission or low disease activity ( LDA ) with apremilast based on disease activity categories and corresponding responses in arthritis and other domains of psoriatic arthritis (PsA) not included in the  cDAPSA .    Methods  Pooled analyses from the Psoriatic Arthritis Long‐term Assessment of Clinical Efficacy studies 1, 2, and 3 were performed. Probability analyses assessing the likelihood of achieving  cDAPSA  treatment targets by week 52 were performed using multiple imputation for discontinuations and missing values. Longitudinal analyses were performed in patients grouped by  cDAPSA  category at week 52.    Results  Among 494 patients in the probability analyses, 46.9% with moderate disease activity and 24.9% with high disease activity at baseline achieved treatment targets (remission or  LDA ) by week 52. For patients with moderate disease activity at baseline, small improvements ( cDAPSA  reductions ≥30%) by week 16 were associated with achieving targets. Patients achieving remission or  LDA  by week 16 had high probabilities of remaining at treatment targets at week 52. Of 375 patients with  cDAPSA  components available at week 52, achieving targets with apremilast was associated with continuous disease activity improvements and no or mild arthritis and other PsA manifestations.    Conclusion  The probability of achieving treatment targets (remission or  LDA ) at week 52 was greater for patients with moderate versus high disease activity at baseline. At a mean level, partial improvements by week 16 were associated with achieving treatment targets. Patients receiving apremilast who achieved  cDAPSA  targets by week 52 also had no or mild arthritis or other PsA manifestations.

Treatment‐to‐Target With Apremilast in Psoriatic Arthritis: The Probability of Achieving Targets and Comprehensive Control of Disease Manifestations