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Spinal Radiographic Progression in Early Axial Spondyloarthritis: Five‐Year Results From the DESIR Cohort
Author(s) -
Ramiro Sofia,
Heijde Désirée,
Sepriano Alexandre,
Lunteren Miranda,
Moltó Anna,
Feydy Antoine,
d'Agostino Maria Antonietta,
Loeuille Damien,
Dougados Maxime,
Reijnierse Monique,
Claudepierre Pascal
Publication year - 2019
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.23796
Subject(s) - medicine , ankylosing spondylitis , axial spondyloarthritis , cohort , radiography , magnetic resonance imaging , spondylitis , nuclear medicine , radiology , surgery , sacroiliitis
Objective To analyze the progression of spinal radiographic damage in patients with early axial spondyloarthritis (SpA). Methods Axial SpA patients from the DESIR (Devenir des Spondylarthropathies Indifférenciées Récentes) cohort with 5‐year spinal (cervical and lumbar) radiographs available (n = 549) were included. Two‐ and 5‐year modified Stoke Ankylosing Spondylitis Spine Score ( mSASSS ) progression and development of new syndesmophytes (net change: the number of patients with positive change minus the number of patients with negative change divided by the total number of patients) were assessed in subgroups defined at baseline according to the Assessment of SpondyloArthritis international Society axial SpA criteria and its arms, modified New York criteria ( mNYC ) and the presence of syndesmophytes. Results Mean ± SD mSASSS progression was 0.2 ± 0.9 at 2 years and 0.4 ± 1.8 at 5 years. Five‐year progression was higher in the imaging arm (mean ± SD 0.6 ± 2.3), magnetic resonance imaging ( MRI )+/ mNYC + (mean ± SD 1.3 ± 4.0), than in the clinical arm only (mean ± SD 0.1 ± 0.7), and highest in patients with syndesmophytes (mean ± SD 2.7 ± 5.0). At 5 years, 7% of all patients had a net change of any new syndesmophyte; this value was 10% for the imaging arm ( mNYC +/ MRI + with 18%), 17% for mNYC + patients, and 42% for patients with syndesmophytes. Conclusion Spinal radiographic progression, although limited in early axial SpA, can be captured after 2 years. Inflammation and damage in the sacroiliac joint are associated with higher radiographic progression. The presence of baseline syndesmophytes already strongly predicts the development of further structural damage early in the disease.