Premium
Increased Burden of Psychiatric Disorders in Rheumatoid Arthritis
Author(s) -
Marrie Ruth Ann,
Hitchon Carol A.,
Walld Randy,
Patten Scott B.,
Bolton James M.,
Sareen Jitender,
Walker John R.,
Singer Alexander,
Lix Lisa M.,
ElGabalawy Renée,
Katz Alan,
Fisk John D.,
Bernstein Charles N.
Publication year - 2018
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.23539
Subject(s) - medicine , rate ratio , incidence (geometry) , depression (economics) , bipolar disorder , anxiety , cohort , population , psychiatry , cohort study , confidence interval , schizophrenia (object oriented programming) , demography , pediatrics , mood , physics , environmental health , sociology , optics , economics , macroeconomics
Objective We estimated the incidence and prevalence of depression, anxiety disorder, bipolar disorder, and schizophrenia in a population‐based cohort with rheumatoid arthritis ( RA ) as compared to an age‐, sex‐, and geographically matched cohort without RA . Methods Using population‐based administrative health data from Manitoba, Canada, we identified persons with incident RA between 1989 and 2012, and a cohort from the general population matched 5:1 on year of birth, sex, and region of residence. We applied validated algorithms for depression, anxiety disorder, bipolar disorder, and schizophrenia to determine the annual incidence of these conditions after the diagnosis of RA , and their lifetime and annual period prevalence. We compared findings between cohorts using negative binomial regression models. Results We identified 10,206 incident cases of RA and 50,960 matched individuals. After adjustment for age, sex, socioeconomic status, region of residence, number of physician visits, and year, the incidence of depression was higher in the RA cohort over the study period (incidence rate ratio [ IRR ] 1.46 [95% confidence interval (95% CI ) 1.35–1.58]), as was the incidence of anxiety disorder ( IRR 1.24 [95% CI 1.15–1.34]) and bipolar disorder ( IRR 1.21 [95% CI 1.00–1.47]). The incidence of schizophrenia did not differ between groups ( IRR 0.96 [95% CI 0.61–1.50]). Incidence rates of psychiatric disorders declined minimally over time. The lifetime and annual period prevalence of depression and anxiety disorder were also higher in the RA than in the matched cohort over the study period. Conclusion The incidence and prevalence of depression, anxiety disorder, and bipolar disorder are elevated in the RA population as compared to a matched population.