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Objective  To describe the characteristics of patients with ankylosing spondylitis ( AS ) and patients with nonradiographic axial spondyloarthritis (SpA) in the  US .    Methods  Demographics, clinical characteristics, patient‐reported outcomes, and treatment characteristics of patients with  AS  and those with nonradiographic axial SpA were assessed at the time of enrollment in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry. Patients with  AS  were defined as those who fulfilled the 1984 modified New York criteria for  AS ; patients with nonradiographic axial SpA were defined as all other patients with axial SpA who did not fulfill the radiology criterion.    Results  Of the 407 patients with a diagnosis of axial SpA who were included in this study, 310 had  AS , and 97 had nonradiographic axial SpA. Although patients with nonradiographic axial SpA were younger and showed a trend toward a shorter symptom duration, the nonradiographic axial SpA and  AS  groups shared a similar disease burden, as reflected by comparisons of disease activity and function, quality of life, pain, fatigue, job absenteeism, and loss of work productivity (all  P  > 0.05). The proportions of patients with nonradiographic axial SpA and patients with  AS  who received prior biologic disease‐modifying drugs ( DMARD s) (74.2% and 64.8%, respectively) or were currently receiving biologic  DMARD s (63.9% and 61.3%, respectively) were also similar ( P  > 0.05).    Conclusion  This was the first nationwide study to characterize patients with  AS  and nonradiographic axial SpA in the  US . Consistent with studies published outside of the  US , this study showed that patients with nonradiographic axial SpA and patients with  AS  shared a comparable degree of disease burden and had similar treatment patterns in clinical practice.

Characterization of Patients With Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis in the US ‐Based Corrona Registry