Open AccessHuman leukocyte antigen associations in postural tachycardia syndrome
Author(s) -
Shin YongWon,
Moon Jangsup,
Kim TaeJoon,
Kim DoYong,
Chang Hyeyeon,
Jun JinSun,
Lee SoonTae,
Jung KeunHwa,
Park KyungIl,
Jung KiYoung,
Kim Manho,
Lee Sang Kun,
Chu Kon
Publication year - 2019
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.766
Subject(s) - medicine , odds ratio , confidence interval , orthostatic vital signs , etiology , postural orthostatic tachycardia syndrome , tachycardia , syncope (phonology) , orthostatic intolerance , human leukocyte antigen , antigen , immunology , blood pressure
Associations between human leukocyte antigen ( HLA ) and postural orthostatic tachycardia syndrome ( POTS ) have not been investigated. We included patients diagnosed with POTS and showing orthostatic heart rate increases ≥ 50 during orthostatic vital sign measurement or experiencing syncope/near‐syncope while standing (prominent POTS ; n = 17). DQB 1*06:09 was present in seven (41%) patients, a significantly higher percentage than in healthy Koreans (7%; odds ratio [ OR ] 8.7, 95% confidence interval [ CI ] 3.1–24.3, corrected P = 3.2 × 10 −4 ) and epilepsy controls (8%; OR 7.9, 95% CI 2.7–23.5, corrected P = 3.2 × 10 −4 ). Six (35.3%) carried the A*33:03‐B*58:01‐C*03:02‐ DRB 1*13:02‐ DQB 1*06:09 haplotype. The results signify an autoimmune etiology in prominent POTS .