Open AccessThe correlation between possible RBD and cognitive function in Parkinson's disease patients in China
Author(s) -
Yan Yayun,
Lei Ke,
Li Yuanyuan,
Liu Xiufeng,
Chang Ying
Publication year - 2019
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.747
Subject(s) - montreal cognitive assessment , medicine , verbal fluency test , cognition , trail making test , parkinson's disease , dementia , audiology , neuropsychology , stroop effect , test (biology) , disease , cognitive impairment , clinical psychology , psychiatry , paleontology , biology
Abstract Objective Cognitive impairment is an important symptom of Parkinson's disease (PD) and seriously affects patients’ quality of life and prognosis. However, its cause is still uncertain. In about one‐third of patients, PD is associated with rapid eye movement sleep behavior disorder (RBD), which is an independent risk factor for PD‐associated dementia; but whether or not it relates to the cognitive function of patients with nondemented PD is still controversial. Methods The data from 89 enrolled PD patients were retrospectively analyzed. The RBD Questionnaire Hong‐Kong (RBD‐HK) was used to diagnose possible RBD (pRBD). There are 46 patients with possible RBD (the PD‐pRBD) and 43 without (the PD‐npRBD). PD disease severity, neuropsychological function, overall cognitive function, and various cognitive functions were assessed. Results There were significant between‐group differences in scores on the Montreal Cognitive Assessment (MoCA), Mini‐Mental State Examination (MMSE), Digit Symbol Test (DST), Trail Making Test‐A (TMT‐A)‐Time, TMT‐Trail Making Test‐B (TMT‐B)‐Time, Stroop Color‐word Test, Clock Drawing Test (CDT), Boston Naming Test (BNT), Verbal Fluency Test (fruit), etc. ( P < 0.05). Interpretation Patients in the PD‐pRBD group had more cognitive impairment.