Open AccessOGTT is recommended for glucose homeostasis assessments in Friedreich ataxia
Author(s) -
Azzi AnneSophie,
Cosentino Cristina,
Kibanda Jésabelle,
Féry Françoise,
Cnop Miriam
Publication year - 2019
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.686
Subject(s) - medicine , ataxia , diabetes mellitus , endocrinology , glucose homeostasis , homeostasis , type 2 diabetes , glucose tolerance test , insulin , insulin resistance , psychiatry
Diabetes is a common complication of Friedreich ataxia, requiring sensitive diagnostic methods. Here, we compared the performance of different tests that assess glucose tolerance, insulin sensitivity, and β ‐cell function in Friedreich ataxia patients, heterozygous FXN mutation carriers and controls. We find that diabetes is underdiagnosed with fasting glucose alone. The oral glucose tolerance test ( OGTT ) provides 1.2‐ to 3.5‐fold more diagnoses of impaired glucose homeostasis and diabetes, and adequately measures insulin sensitivity, insulin secretion, and β ‐cell function. Clinicians in charge of Friedreich ataxia patients and researchers should incorporate the OGTT as an accurate diagnostic and research tool.