Open AccessG1m1 predominance of intrathecal virus‐specific antibodies in multiple sclerosis
Author(s) -
TomescuBaciu Alina,
Vartdal Frode,
Holmøy Trygve,
Vedeler Christian A.,
Lossius Andreas
Publication year - 2018
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.642
Subject(s) - medicine , intrathecal , multiple sclerosis , immunology , allotype , meningoencephalitis , antibody , neuroborreliosis , immune system , rubella , virus , meningitis , measles virus , varicella zoster virus , cerebrospinal fluid , virology , measles , pathology , vaccination , borrelia burgdorferi , surgery , psychiatry
We have previously shown that plasmablasts of the G1m1 allotype of IgG1 are selectively enriched in the cerebrospinal fluid of G1m1/G1m3 heterozygous patients with multiple sclerosis, whereas both allotypes are equally used in neuroborreliosis. Here, we demonstrate a strong preference for the G1m1 allotype in the intrathecal humoral immune responses against measles, rubella, and varicella zoster virus in G1m1/G1m3 heterozygous multiple sclerosis patients. Conversely, intrathecally synthesized varicella zoster virus‐specific IgG1 in varicella zoster virus meningoencephalitis comprised both allotypes. This implies that G1m1 B cells are selected to the central nervous system of multiple sclerosis patients regardless of specificity and suggests that an antigen‐independent mechanism could drive the intrathecal humoral immune response.