Open AccessDecreased plasma C‐reactive protein levels in APOE ε 4 allele carriers
Author(s) -
Martiskainen Henna,
Takalo Mari,
Solomon Alina,
Stančáková Alena,
Marttinen Mikael,
Natunen Teemu,
Haapasalo Annakaisa,
Herukka SannaKaisa,
Kuusisto Johanna,
Soininen Hilkka,
Kivipelto Miia,
Laakso Markku,
Hiltunen Mikko
Publication year - 2018
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.639
Subject(s) - apolipoprotein e , medicine , allele , dementia , c reactive protein , endocrinology , inflammation , cohort , apolipoprotein b , metabolic syndrome , cholesterol , disease , genetics , obesity , biology , gene
Objective Apolipoprotein E ( APOE ) ε 4 allele is a well‐established risk factor in Alzheimer's disease ( AD ). Here, we assessed the effects of APOE polymorphism on cardiovascular, metabolic, and inflammation‐related parameters in population‐based cohorts. Methods Association of cardiovascular, metabolic, and inflammation‐related parameters with the APOE polymorphism in a large Finnish Metabolic Syndrome in Men ( METSIM ) cohort and Finnish Geriatric Intervention study to prevent cognitive impairment and disability ( FINGER ) were investigated. Brain‐specific effects were addressed in postmortem brain samples. Results Individuals carrying the APOE ε 4 allele displayed significantly elevated serum/plasma LDL cholesterol and apolipoprotein B levels. APOE ε 3 ε 4 and ε 4 ε 4 significantly associated with lower levels of plasma high‐sensitivity C‐reactive protein (hs‐ CRP ). Plasma amyloid‐ β 42 (A β 42) and reduced hs‐ CRP levels showed an association independently of the APOE status. Interpretation These data suggest that the APOE ε 4 allele associates with lower levels of hs‐ CRP in individuals without dementia. Moreover, A β 42 may encompass anti‐inflammatory effects reflected by reduced hs‐ CRP levels.