Open AccessAging and APOE ‐ε4 are determinative factors of plasma A β 42 levels
Author(s) -
Nakamura Takumi,
Kawarabayashi Takeshi,
Seino Yusuke,
Hirohata Mie,
Nakahata Naoko,
Narita Sakiko,
Itoh Ken,
Nakaji Shigeyuki,
Shoji Mikio
Publication year - 2018
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.635
Subject(s) - apolipoprotein e , determinative , medicine , cognition , plasma levels , function (biology) , biomarker , endocrinology , chemistry , biology , disease , biochemistry , microbiology and biotechnology , linguistics , philosophy , psychiatry
Objective The aim of this study was to confirm determinative factors for plasma A β and its association with cognitive function. Methods Fasting plasma A β 40 and A β 42 levels were measured by ELISA in 1019 participants in the Iwaki Health Promotion Project. The relationships between plasma A β and health‐related items, including physical characteristics, cognitive function tests, blood chemistry, and APOE ‐ε4 genotype were analyzed. Results The plasma levels of A β 40 and A β 42, and A β 40/42 ratio were found to significantly increase with aging. The age‐dependent increase in A β 42 level was significantly suppressed by APOE ‐ε4 . Renal function was an associated factor for the plasma A β 40 level. The plasma A β 42 level and A β 40/42 ratio correlated with cognitive function. Interpretation Age and APOE ‐ε4 are major determinative factors of plasma levels of A β 42 and the A β 40/42 ratio. These factors are critical adjustment factors for the usage of plasma A β as a biomarker of central nervous system amyloidosis.