Open AccessEffect of smoking cessation on the risk of dementia: a longitudinal study
Author(s) -
Choi Daein,
Choi Seulggie,
Park Sang Min
Publication year - 2018
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.633
Subject(s) - medicine , dementia , hazard ratio , cohort , cohort study , confidence interval , smoking cessation , vascular dementia , population , disease , gerontology , environmental health , pathology
Objective To determine the risk of developing dementia in relation to duration of smoking cessation by using a nationwide health claims database. Methods This cohort study included 46,140 men aged 60 years or older from Korean National Health Insurance System – National Health Screening Cohort, a population‐based national health screening program from 2002 to 2013. The changes in smoking habit from a questionnaire during the first (2002 and 2003) and second (2004 and 2005) health examination periods, participants were divided into continual smokers, short‐term (less than 4 years) quitters, long‐term (4 years or more) quitters, and never smokers. Participants were followed‐up for 8 years from January 1, 2006 for the development of overall dementia, Alzheimer's disease, and vascular dementia. Results Compared to continual smokers, long‐term quitters and never smokers had decreased risk of overall dementia (hazard ratio, HR 0.86 95% CI , confidence interval 0.75–0.99 and HR : 0.81; 95% CI : 0.71–0.91, respectively). Never smokers had decreased risk of Alzheimer's disease ( HR : 0.82; 95% CI : 0.70–0.96) compared to continual smokers. Finally, both long‐term quitters ( HR : 0.68; 95% CI : 0.48–0.96) and never smokers ( HR : 0.71; 95% CI : 0.54–0.95) had decreased risk of vascular dementia compared to continual smokers. Interpretation Smoking was associated with increased risk of dementia. Smokers who quit for a prolonged period of time may benefit from reduced risk of dementia. Therefore, smokers should be encouraged to quit in order to reduce the risk of developing dementia, especially in the elderly population who are already at risk.