Open AccessCombined respiratory training in an individual with C9orf72 amyotrophic lateral sclerosis
Author(s) -
Robison Raele,
TaborGray Lauren C.,
Wymer James P.,
Plowman Emily K.
Publication year - 2018
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.623
Subject(s) - amyotrophic lateral sclerosis , medicine , c9orf72 , vital capacity , respiratory system , centimeter , physical therapy , physical medicine and rehabilitation , anesthesia , cardiology , surgery , lung function , lung , diffusing capacity , disease , dementia , frontotemporal dementia
This case study examined the impact of a respiratory strength training program targeting inspiratory and expiratory musculature in an individual with C9orf72 amyotrophic lateral sclerosis ( ALS ). The individual tolerated 24 months of respiratory training completed at home, 50 repetitions per day, and 5 days per week. Significant increases in maximum inspiratory pressure (from 71 to 134 centimeters of water), maximum expiratory pressure (from 108 to 197 centimeters of water) and peak cough flow (from 331 to 655 Liters per minute) were noted and forced vital capacity remained unchanged. A moderate intensity respiratory strength training program applied early in the disease progression improved function in this C9orf72 ALS individual.