Open AccessDeep cerebral vein expansion with metabolic and neurocognitive recovery in Sturge–Weber syndrome
Author(s) -
John Flóra,
Maqbool Mohsin,
Jeong Jeongwon,
Agarwal Rajkumar,
Behen Michael E.,
Juhász Csaba
Publication year - 2018
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.546
Subject(s) - medicine , neurocognitive , sturge–weber syndrome , levetiracetam , piracetam , aspirin , neuroimaging , cardiology , anesthesia , radiology , epilepsy , surgery , cognition , psychiatry
We present longitudinal imaging data of a child with Sturge–Weber syndrome ( SWS ). At age 8 months, 3 weeks after initial seizures and prolonged motor deficit, MRI showed extensive right hemispheric SWS involvement with severe glucose hypometabolism on PET . She was treated with levetiracetam and aspirin. Follow‐up imaging at age 29 months showed a robust interval expansion of enlarged deep medullary veins throughout the affected hemisphere along with a dramatic recovery of hemispheric metabolism and normalized neurocognitive functioning. These findings demonstrate a robust, multilobar hemispheric remodeling of deep venous collaterals that likely contributed to reversal of initial metabolic and neurocognitive deficits.