Open AccessAutoimmune postural orthostatic tachycardia syndrome
Author(s) -
Watari Mari,
Nakane Shunya,
Mukaino Akihiro,
Nakajima Makoto,
Mori Yukiko,
Maeda Yasuhiro,
Masuda Teruaki,
Takamatsu Koutaro,
Kouzaki Yanosuke,
Higuchi Osamu,
Matsuo Hidenori,
Ando Yukio
Publication year - 2018
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.524
Subject(s) - medicine , antibody , orthostatic vital signs , postural orthostatic tachycardia syndrome , antecedent (behavioral psychology) , autoantibody , acetylcholine receptor , immunology , receptor , psychology , developmental psychology , blood pressure
The aim of this study was to evaluate the association between postural orthostatic tachycardia syndrome ( POTS ) and circulating antiganglionic acetylcholine receptor ( gAChR ) antibodies. We reviewed clinical assessments of Japanese patients with POTS , and determined the presence of gAChR antibodies in serum samples from those patients. Luciferase immunoprecipitation systems detected anti‐ gAChR α 3 and β 4 antibodies in the sera from POTS (29%). Antecedent infections were frequently reported in patients in POTS patients. Moreover, autoimmune markers and comorbid autoimmune diseases were also frequent in seropositive POTS patients. Anti‐ gAChR antibodies were detectable in significant number of patients with POTS , and POTS entailed the element of autoimmune basis.