Open AccessLongitudinal change in TSPO PET imaging in progressive multiple sclerosis
Author(s) -
Kang Yeona,
Pandya Sneha,
Zinger Nicole,
Michaelson Nara,
Gauthier Susan A.
Publication year - 2021
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.51431
Subject(s) - medicine , multiple sclerosis , putamen , white matter , thalamus , pet imaging , magnetic resonance imaging , pathology , nuclear medicine , positron emission tomography , radiology , immunology
The objective of this pilot study was to assess a 2‐year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195‐PET. Sixteen age‐matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal‐appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM ( p = 0.01), cortex ( p = 0.04), thalamus ( p = 0.04), and putamen ( p = 0.02) at 12 months. Among patients remaining at 24 months, there was no further increase in PK11195. Our data suggest that innate immune activity may increase over time in patients with progressive MS.