Open AccessInfiltration of plasma cells in colorectal adenocarcinoma associated with autoimmune encephalitis
Author(s) -
Shu Yaqing,
He Dan,
Ma Xiaoyu,
Li Jianfang,
Wu Haotian,
Chen Chen,
Lu Zhengqi,
Petersen Frank,
Qiu Wei,
Yu Xinhua
Publication year - 2021
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.51283
Subject(s) - medicine , infiltration (hvac) , autoimmune encephalitis , adenocarcinoma , antigen , colorectal cancer , antibody , pathology , neoplasm , lung , immunology , cancer , autoantibody , physics , thermodynamics
Paraneoplastic autoimmune encephalitis (PAE) represents a group of rare neurological syndromes associated with neoplastic diseases. Here, we report a case that multiple anti‐neuronal antibodies were present in a patient with PAE who developed both small cell lung cancer and colorectal adenocarcinoma. Furthermore, the immunopathological investigation of the colorectal adenocarcinoma revealed the formation of abnormal neuronal antigens and a massive infiltration of plasma cells in the tumor tissue. These findings support the hypothesis that expression of neuronal antigens in neoplasm initiates autoimmune responses in PAE.