Open AccessPlasma lipidomics of monozygotic twins discordant for multiple sclerosis
Author(s) -
Penkert Horst,
Lauber Chris,
Gerl Mathias J.,
Klose Christian,
Damm Markus,
Fitzner Dirk,
FlierlHecht Andrea,
Kümpfel Tania,
Kerschensteiner Martin,
Hohlfeld Reinhard,
Gerdes Lisa A.,
Simons Mikael
Publication year - 2020
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.51216
Subject(s) - lipidomics , medicine , multiple sclerosis , pathophysiology , monozygotic twin , bioinformatics , immunology , biology , genetics
Abstract Blood biomarkers of multiple sclerosis (MS) can provide a better understanding of pathophysiology and enable disease monitoring. Here, we performed quantitative shotgun lipidomics on the plasma of a unique cohort of 73 monozygotic twins discordant for MS. We analyzed 243 lipid species, evaluated lipid features such as fatty acyl chain length and number of acyl chain double bonds, and detected phospholipids that were significantly altered in the plasma of co‐twins with MS compared to their non‐affected siblings. Strikingly, changes were most prominent in ether phosphatidylethanolamines and ether phosphatidylcholines, suggesting a role for altered lipid signaling in the disease.