Open AccessTest–retest reliability of the Friedreich’s ataxia rating scale
Author(s) -
Rummey Christian,
Zesiewicz Theresa A.,
PerezLloret Santiago,
Farmer Jennifer M.,
Pandolfo Massimo,
Lynch David R.
Publication year - 2020
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.51118
Subject(s) - intraclass correlation , medicine , rating scale , ataxia , reliability (semiconductor) , physical therapy , clinical trial , standard error , physical medicine and rehabilitation , test (biology) , psychometrics , statistics , clinical psychology , psychiatry , paleontology , power (physics) , physics , mathematics , quantum mechanics , biology
The modified Friedreich Ataxia Rating Scale (mFARS) is a disease specific, exam‐based neurological rating scale commonly used as a outcome measure in clinical trials. While extensive clinimetric testing indicates it’s validity in measuring disease progression, formal test–retest reliability was lacking. To fill this gap, we acquired results from screening and baseline visits of several large clinical trials and calculated intraclass correlation coefficients, coefficients of variance, standard error, and the minimally detectable changes. This study demonstrated excellent test–retest reliability of the mFARS, and it’s upright stability subscore.