Open AccessIn vivo evolution of biopsy‐proven inflammatory demyelination quantified by R2t* mapping
Author(s) -
Xiang Biao,
Wen Jie,
Lu HsiangChih,
Schmidt Robert E.,
Yablonskiy Dmitriy A.,
Cross Anne H.
Publication year - 2020
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.51052
Subject(s) - medicine , biopsy , lesion , in vivo , pathology , quadrant (abdomen) , brain biopsy , radiology , microbiology and biotechnology , biology
A 35‐year‐old man with an enhancing tumefactive brain lesion underwent biopsy, revealing inflammatory demyelination. We used quantitative Gradient‐Recalled‐Echo (qGRE) MRI to visualize and measure tissue damage in the lesion. Two weeks after biopsy, qGRE showed significant R2t* reduction in the left optic radiation and surrounding tissue, consistent with the histopathological and clinical findings. qGRE was repeated 6 and 14 months later, demonstrating partially recovered optic radiation R2t* , in concert with improvement of the hemianopia to ultimately involve only the lower right visual quadrant. These results support qGRE metrics as in vivo biomarkers for tissue damage and longitudinal monitoring of demyelinating disease.